Dr. Sophie Bots is an Assistant Professor in Pharmacoepidemiology Methods working for the Pharmacoepidemiology & Clinical Pharmacoloy department of Utrecht University. She has a background in Epidemiology and has experience with using regular care data for research from her PhD, which focussed on sex differences in the safety and efficacy of cardiovascular medication. Her current work focusses on the methodological challenges surrounding the use of observational real world data for research, specifically on the topics of COVID-19 vaccine safety and sex differences in de safety and dosage of cardiovascular medication.