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RISING STAR IN ENTREPRENEURSHIP


Annegret Van der Aa

CEO & Executive Director
Cantoni Therapeutics


About Annegret van der Aa

Annegret Van der Aa is a seasoned strategical and operational R&D leader and brings nearly 25 years of drug discovery and development experience. Annegret held various leadership positions in both mid-size and start up biotech companies and has a passion to ‘build’ teams, departments, companies, by bringing together talented professionals to move programs forward in the most efficient way.

Since July 2024 she has joined Cantoni Therapeutics (Oss, NL) as Chief Executive Officer and Executive Director. Before, she was CSO/CDO at Ermium Therapeutics (France), a discovery stage company working on small molecules targeting complex autoimmune diseases, and COO at OCTIMET Oncology (Belgium), a clinical-stage company developing MET kinase inhibitors for precision oncology indications. Between 2010 and 2018, she was at Galapagos (Belgium) and took up different positions in the Development organisation, transitioning more than 10 preclinical compounds to clinical stage and she was instrumental in the clinical development of Jyseleca® (filgotinib), approved for a first indication in 2020. Before, she was Project Leader at ActoGeniX (now Precigen ActoBio) and Unit Manager Immunology at Innogenetics (now Fujirebio). Annegret holds a Master in Biochemistry from University Antwerp and a PhD in Biomedical Sciences – Immunology from University Hasselt (Belgium).


About Cantoni Therapeutics 

Cantoni Therapeutics B.V., founded in December 2022 as a spinout from University Leiden is pioneering the discovery and development of bisubstrate small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), a metabolic enzyme highly expressed in metabolic tissues, including the liver, adipose tissue and muscle. NNMT is an attractive drug target for cardiometabolic disease where elevated NNMT levels are correlated with obesity, type 2 diabetes and cardiovascular diseases. In diet-induced obese mice, Cantoni’s NNMT inhibitors induce a reduction in fat mass, without negatively impacting lean mass, and improved metabolic health through increased energy expenditure rather than reduced energy intake. Furthermore, targeting this metabolic enzyme also brings opportunities in other indications; a role for NNMT has been described in the development of chronic kidney disease as well as in cancer progression.

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