Harvard Business Case


Liesbeth Hof | Sr Director Project Management, AM-Pharma

Liesbeth Hof holds a Master in Medical Biology and brings over 20 years of international experience in the pharmaceutical and biotech industries. Her career began at the Ministry of Health, after which she gained invaluable experience at Novartis in Switzerland, and later United Kingdom, specializing in  global regulatory affairs. Transitioning from big pharma, she joined the consultancy firm ProPharma Group, where she led a team of consultants, was engaged in business development and supported start-ups and biotech companies with their development programs. Since 2022, Liesbeth has been working with AM-Pharma, where she oversees project management for development programs and ensures operational implementation. Throughout her career, Liesbeth drove diverse cross-functional global team, achieving successful regulatory submissions across various therapeutic areas, including orphan drugs. She has also played a pivotal role in strategic planning and milestone achievement at key stages of the product’s life cycle. 



AM-Pharma

AM-Pharma’s purpose is to save and improve the lives of patients confronted with severe medical conditions. Our initial focus is acute kidney injury, impacting hundreds of thousands of people hospitalized each year. Our proprietary compound, ilofotase alfa, has the potential to become the first treatment for acute kidney injury and its potential effect has been demonstrated in almost 1,000 patients in global clinical trials.  We are also developing ilofotase alfa in the severe rare disease Hypophosphatasia. We are a dedicated team driven to bring treatment options to severely ill patients, their families and specialty care professionals.

Find out more about us online at: www.am-pharma.com.

Harvard Business Case

AM-Pharma is a biotech company developing a medicine for patients with acute kidney injury. The case describes the company's journey from inception in 2001 to a large deal with Pfizer in 2015. The aim is to discuss the value creation of AM-Pharma through its strategic decisions over time. It highlights the patient journey, company challenges, market size potential, and how the management team was able to raise multiple financing rounds from venture capitalists. It further provides the readers with a unique insight in the key risks and operational challenges of a biotech company and the value of an experienced management team backed by strong investors. The drug development process is inherently risky, long and expensive and the probability of commercializing a new drug is very low. The company's CEO is the protagonist and the case is split in three parts to provide the readers with surprises and open strategic questions which are time related. The case is semi-chronologically and a patient story is intermingled to provide a different perspective on clinical trials, ethical dilemmas and the high unmet medical need for new therapies. The case ends with a valuation simulation, in which the readers can negotiate the AM-Pharma/Pfizer deal themselves.  

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