Narrative cv coming soon 

Abstract: A major challenge in cancer therapy is the inefficient delivery of chemotherapeutic agents to tumors. Systemic drugs often show poor tumor accumulation, leading to off-target toxicity and reduced efficacy. While liposomes can encapsulate drugs and passively accumulate in tumors, passive targeting rarely achieves controlled or efficient release. Ultrasound provides a safe, non-invasive method to trigger localized drug release, minimizing systemic exposure. To achieve ultrasound-triggerable drug release, Ignasi has led mechanistic studies of liposome–ultrasound interactions, combining computational simulations with experimental techniques such as stability testing, differential scanning calorimetry, small-angle neutron scattering, and atomic force microscopy. This multidisciplinary approach revealed how lipid composition affects release efficiency, enabling the rational design of formulations that balance release and stability. In parallel, ultrasound parameters—frequency, pressure, pulse repetition frequency, and duty cycle—are optimized using custom-built transducers and COMSOL simulations. This ensures precise, effective drug release within FDA-compliant ultrasound settings. Ignasi’s work bridges a key gap between ultrasound physics and nanomedicine, providing critical insights for the rational design of ultrasound-triggerable drug delivery systems.